Best Enzyme Cleaners For Pets

Looking for the best enzyme cleaners for pets? We’ve tested and reviewed the top 10 options to help you find the perfect one for tackling pet messes with ease.

Pet messes can be tough to clean, but the right enzyme cleaner makes it easy. These powerful formulas break down stains and odors, leaving your home fresh and clean.

We’ve tested and reviewed the best enzyme cleaners for pets, so you can find the perfect one. They’re safe, effective, and work on everything from carpets to drains.

List of Top 10 Enzyme Cleaners For Pets

Image Title Best For Price
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home – Carpet Stain Remover for Cats & Dog Pee – Urine Destroyer – Carpet Cleaner Spray Clear, 32 Fl Oz

This pet odor eliminator is perfect for pet owners who want a safe and effective way to clean up messes. It’s great for homes with cats and dogs, removing stains and smells from carpets, floors, and furniture.

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Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

This multi-purpose cleaner is perfect for anyone who wants a powerful, natural solution for tough cleaning jobs. It’s great for homes, pets, and busy spaces where odors and stains need to be tackled fast.

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Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home – Carpet Stain Remover for Cats & Dog Pee – Urine Destroyer – Carpet Cleaner Spray, 1-Gallon

This pet odor eliminator is perfect for pet owners who want a safe and effective way to clean up messes. It’s great for homes with cats and dogs, working on carpets, floors, and furniture.

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Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) – Pet Stain and Odor Remover – Concentrated – Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA

This multi-purpose cleaner is perfect for anyone who wants a powerful, natural solution for tough stains and odors. It’s great for pet owners, busy families, or professional cleaners needing a reliable, versatile product.

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Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

This product is perfect for pet owners who want to keep their homes clean and fresh. It’s great for anyone dealing with pet messes like urine, poop, or vomit.

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Eco Strong Pet Stain and Odor Remover - Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner - 32 OZ Eco Strong Pet Stain and Odor Remover – Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner – 32 OZ

This product is perfect for pet owners who want to quickly and easily clean up accidents. It’s great for carpets, bedding, litter boxes, and more.

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Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon) Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

This multi-purpose enzyme cleaner is perfect for pet owners, busy families, and anyone dealing with tough stains and odors. It’s safe for kids, pets, and all surfaces, making it ideal for homes, vets, and cleaners.

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Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil Pet Odor and Stain Eliminator – 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets – Natural Citrus Oil

This pet odor and stain eliminator is perfect for pet owners who want to keep their homes clean and fresh. It’s great for anyone with dogs or cats that need to tackle messes on carpets, furniture, or floors.

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AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack

This AmazonCommercial Multi-Purpose Enzyme Cleaner is perfect for anyone who needs a powerful, all-in-one solution to tackle tough stains and odors. It’s great for pet owners, businesses, and homes alike, making cleaning easier in any space.

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Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon

Urine B-Gone is perfect for pet owners and families who want a fresh, clean home. It’s safe for kids and pets and works fast on tough stains and odors.

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Detailed Reviews

Discover the top 10 enzyme cleaners for pets, carefully selected based on expert reviews and customer feedback. Each product is thoroughly reviewed to highlight its features, performance, and value. Whether you need a cleaner for tough stains or strong odors, this guide has you covered. Find the perfect enzyme cleaner to keep your home fresh and pet-friendly with ease.

1. Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home – Carpet Stain Remover for Cats & Dog Pee – Urine Destroyer – Carpet Cleaner Spray Clear, 32 Fl Oz

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Rocco & Roxie Stain & Odor Eliminator is a powerful enzyme cleaner that removes tough stains and odors from pet messes. It’s safe for pets, kids, and all carpets, with a Seal of Approval from the Carpet and Rug Institute.

Use it anywhere stains happen—carpets, floors, furniture, or clothes. It works on urine, feces, vomit, and more, leaving no residue or smell behind.

Pros Cons
  • Safe for pets, kids, and carpets with CRI approval.
  • Removes stains and odors from pet messes completely.
  • Works on all surfaces where pets live and play.
  • Chlorine-free and no residue for clean, fresh results.
  • Strong smell may linger, not ideal for sensitive noses.
  • Not for tough, old stains; works best on fresh ones.
  • Price is higher than some other cleaners.

Perfect For:

This pet odor eliminator is perfect for pet owners who want a safe and effective way to clean up messes. It’s great for homes with cats and dogs, removing stains and smells from carpets, floors, and furniture.

Ready to Purchase?

2. Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Bioda Multi-Purpose Probiotic Enzyme Cleaner is a powerful, all-in-one solution for your cleaning needs. It tackles tough stains, odors, and more with natural, long-lasting results.

This cleaner uses specialized probiotics that keep working for up to 21 days. Simply spray and let it do the hard work for you. It’s perfect for drains, trash cans, floors, and more.

Made in the USA, this 1-gallon bottle is safe and effective. It leaves a fresh lemon and sage scent without harmful residues. Trust Bioda for a clean, odor-free home.

Pros Cons
  • One product for all cleaning needs, saving time and money.
  • Probiotics work up to 21 days, keeping surfaces clean longer.
  • Naturally eliminates odors and stains without harsh chemicals.
  • Fresh scent of lemon and sage leaves spaces smelling great.
  • Proudly made in the USA, ensuring quality and reliability.
  • Strong scent may not suit everyone’s preference.
  • Large size might be bulky for small storage spaces.
  • Price could be higher than basic cleaners.

Perfect For:

This multi-purpose cleaner is perfect for anyone who wants a powerful, natural solution for tough cleaning jobs. It’s great for homes, pets, and busy spaces where odors and stains need to be tackled fast.

Ready to Purchase?

3. Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home – Carpet Stain Remover for Cats & Dog Pee – Urine Destroyer – Carpet Cleaner Spray, 1-Gallon

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator is a powerful enzyme cleaner that removes tough stains and odors caused by pets. It’s safe for all carpets and surfaces, making it perfect for homes with cats and dogs.

This cleaner works on carpets, floors, furniture, and more. It’s chlorine-free and safe for pets and kids. Buy with confidence—it’s certified and trusted.

Pros Cons
  • Safe for pets, kids, and all carpetscertified by CRI.
  • Eliminates stains and odors from pet messesguaranteed.
  • Works on every surfacecarpets, clothes, furniture, and more.
  • Professional strength, chlorine-free, and no residue left behind.
  • Not for tough, old stains – Fresh messes only.
  • Large size – Takes up storage space.
  • Enzyme formula – May need extra time to work.

Perfect For:

This pet odor eliminator is perfect for pet owners who want a safe and effective way to clean up messes. It’s great for homes with cats and dogs, working on carpets, floors, and furniture.

Ready to Purchase?

4. Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) – Pet Stain and Odor Remover – Concentrated – Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA

Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA

This multi-purpose cleaner tackles tough stains and odors. It works on floors, bathrooms, and drains. Perfect for home or professional use.

The probiotic technology breaks down grime naturally. It removes pet stains and odors without harsh chemicals.

Safe for tile, porcelain, and concrete. Use it regularly for a fresh, clean space.

Pros Cons
  • Powerful cleaner for all surfaces, from floors to drains.
  • Natural probiotics break down stains and grime effortlessly.
  • Eliminates odors, not just masks them, for a fresh space.
  • Concentrated formula lasts longer, saving you time and money.
  • Safe for regular use on multiple surfaces, including tile and concrete.
  • Concentrated formula needs dilution, extra step for users.
  • Not for unsealed surfaces, limits usage areas.
  • Large size may be too much for small spaces.

Perfect For:

This multi-purpose cleaner is perfect for anyone who wants a powerful, natural solution for tough stains and odors. It’s great for pet owners, busy families, or professional cleaners needing a reliable, versatile product.

Ready to Purchase?

5. Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Rocco & Roxie Extreme Stain & Odor Eliminator tackles tough stains and strong odors from pets. It works on urine, vomit, and more, leaving a fresh, Meyer lemon scent. This cleaner is safe for pets and kids when used as directed.

It’s fast-acting and works on any surface, from carpets to cars. The bio-enzymatic formula breaks down organic matter and ammonia crystals for deep cleaning.

Certified by the Carpet and Rug Institute, it’s safe for all carpets. If you’re not satisfied, the company promises to make it right.

Pros Cons
  • Removes stains, odors, and residue from pet accidents.
  • Works on all surfaces, from carpets to clothing.
  • Safe for pets, kids, and carpets with CRI approval.
  • Fast-acting enzymes neutralize odors at the source.
  • Strong scent may not suit everyone’s preference.
  • Higher price compared to basic cleaners.
  • Requires multiple applications for very old stains.

Perfect For:

This product is perfect for pet owners who want to keep their homes clean and fresh. It’s great for anyone dealing with pet messes like urine, poop, or vomit.

Ready to Purchase?

6. Eco Strong Pet Stain and Odor Remover – Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner – 32 OZ

Eco Strong Pet Stain and Odor Remover - Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner - 32 OZ

Eco Strong Pet Stain and Odor Remover is a powerful enzyme cleaner that tackles pet stains and smells. It works on urine, poop, vomit, and more, breaking down odor-causing proteins without harsh chemicals.

Safe for carpets, furniture, and even laundry, it’s non-toxic and made in the USA. Use it on litter boxes, bedding, or pet accidents for fresh, clean results.

Pros Cons
  • Removes stains and odors with natural enzymes.
  • Safe for pets, kids, and all surfaces.
  • Works on carpets, beds, and litter boxes.
  • Made in the USA, non-toxic, and eco-friendly.
  • Not for all surfaces: Avoid using on delicate fabrics or unwashed leather.
  • Requires time: Enzymes need time to fully break down stains and odors.
  • Spray bottle: Some users may prefer a different applicator for larger areas.

Perfect For:

This product is perfect for pet owners who want to quickly and easily clean up accidents. It’s great for carpets, bedding, litter boxes, and more.

Ready to Purchase?

7. Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

Say goodbye to stains and odors with this powerful enzyme cleaner. It works fast to break down messes and keep your home fresh.

Safe for pets, kids, and all surfaces, it’s trusted by pros and easy to use. Perfect for carpets, laundry, and drains.

Pros Cons
  • Powerful enzymes break down stains and odors fast.
  • Safe for pets, kids, and all surfaces.
  • Eliminates urine and waste smells in seconds.
  • Multi-purpose cleaner for home and commercial use.
  • Strong scent may be too overpowering for some users.
  • Large size might take up extra storage space.
  • Price could be higher than basic cleaners.

Perfect For:

This multi-purpose enzyme cleaner is perfect for pet owners, busy families, and anyone dealing with tough stains and odors. It’s safe for kids, pets, and all surfaces, making it ideal for homes, vets, and cleaners.

Ready to Purchase?

8. Pet Odor and Stain Eliminator – 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets – Natural Citrus Oil

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

Say goodbye to pet stains and odors with our ACTIVE Enzyme Cleaner. This ready-to-use spray targets the source of messes, leaving a fresh citrus scent.

It’s safe for pets and kids, works on carpets, floors, and furniture, and is made in the USA. Easy to use, powerful results.

Pros Cons
  • Removes odors and stains completely, leaving fresh citrus scent.
  • Powerful enzymes tackle pet messes like urine, vomit, and poop.
  • Safe for pets, kids, and all home surfaces.
  • Made in USA with quality ingredients.
  • Long soaking time needed for best results.
  • Multiple steps required for tough stains.
  • Citrus scent may not appeal to everyone.

Perfect For:

This pet odor and stain eliminator is perfect for pet owners who want to keep their homes clean and fresh. It’s great for anyone with dogs or cats that need to tackle messes on carpets, furniture, or floors.

Ready to Purchase?

9. AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack

AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack

AmazonCommercial Multi-Purpose Enzyme Cleaner is a powerful solution for tough stains and odors. It comes in a 1-gallon bottle, perfect for large areas. Use it on carpets, surfaces, and drains.

This cleaner breaks down organic proteins, pet smells, and grease. It works well in commercial spaces, retail stores, and hotels. Apply it directly to problem areas for effective results.

Keep your environment clean and fresh with this reliable cleaner. It’s a must-have for spot cleaning and maintenance.

Pros Cons
  • Removes stains and odors fast with powerful enzymes.
  • Works on carpets, drains, toilets, and more surfaces.
  • Perfect for homes, businesses, and busy areas.
  • Tackles pet mess, grease, and oils easily.
  • Not for all surfaces, may damage some materials.
  • Large size might be too bulky for small spaces.
  • Strong scent could be overpowering for sensitive noses.

Perfect For:

This AmazonCommercial Multi-Purpose Enzyme Cleaner is perfect for anyone who needs a powerful, all-in-one solution to tackle tough stains and odors. It’s great for pet owners, businesses, and homes alike, making cleaning easier in any space.

Ready to Purchase?

10. Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon

Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon

Urine B-Gone is a powerful cleaner that removes pet and human stains. It works on carpets, laundry, and more. The lavender scent leaves your home fresh.

This enzyme formula attacks odors at the source. It’s safe for pets and kids when used right.

Use it for drains, toilets, and tough stains. Kinzua Environmental makes it strong yet gentle.

Pros Cons
  • Eliminates odors and stains with 200 billion microbes.
  • Deep cleans carpets, upholstery, and floors for lasting freshness.
  • Safe for pets, kids, and home use.
  • Versatile for laundry, drains, and toilets.
  • Strong lavender scent may not appeal to everyone’s taste.
  • Large 1-gallon size might be bulky for small storage spaces.
  • Requires time to fully eliminate deep-set stains and odors.

Perfect For:

Urine B-Gone is perfect for pet owners and families who want a fresh, clean home. It’s safe for kids and pets and works fast on tough stains and odors.

Ready to Purchase?

Buying Guide

Pet messes are no match for the right enzyme cleaner. These powerful formulas make cleaning easy and leave your home fresh.

Choosing the best enzyme cleaner for pets can be fun. You’ll find one that fits your needs and keeps your space clean. Here’s what to look for:

  • Type of Mess: Think about what you’re cleaning. Some cleaners work best on urine, while others tackle vomit or feces.
  • Surface Use: Check if the cleaner is safe for carpets, furniture, or hard floors. Some are even safe for laundry.
  • Scent: Choose a scent you like, such as lemon, lavender, or citrus. A fresh smell makes cleaning more enjoyable.
  • Safety: Look for cleaners that are pet-safe and kid-safe. Avoid harsh chemicals for a healthier home.
  • Size: Decide if you need a small spray bottle or a large gallon jug. Bigger sizes are great for frequent use.
  • Longevity: Some cleaners keep working for days. This is handy for drains or trash cans.
  • Certifications: Trust cleaners with a Seal of Approval from the Carpet and Rug Institute. They’re tested and proven.
  • Ease of Use: Pick a cleaner that’s ready to use or easy to mix. Simple steps save time and effort.